期刊
PHYTOTHERAPY RESEARCH
卷 30, 期 2, 页码 267-271出版社
WILEY
DOI: 10.1002/ptr.5526
关键词
Ziziphus jujuba; Rhamnaceae; heme iron recycling; heme oxygenase-1; anti-oxidant response element
资金
- Hong Kong Research Grants Council [T13-607/12R]
- GRF [661110, 662911, 660411, 663012, 662713, M-HKUST604/13]
- Hong Kong Jockey Club Charities Trust [HKJCCT12SC01]
- Foundation of The Awareness of Nature [TAON12SC01]
- Ministry of Human Resources and Social Security of the People's Republic of China
- National Science Foundation of Guangdong Province [2015A030310247]
- Traditional Chinese Medicine Bureau of Guangdong Province [20151079]
- Health and Family Planning Commission of Shenzhen Municipality [201505015]
- Hong Kong Chiu Chow Chamber of Commerce
- [TUYF12SC03]
- [TUYF15SC01]
Jujube, the fruit of Ziziphus jujuba Mill., is a functional food and commonly used as a health supplement worldwide. To study the beneficial role of jujube in heme iron recycling during erythrophagocytosis, the expression of heme oxygenase-1 (HO-1), biliverdin reductase A and B, and ferroportin were determined in jujube-treated cultured RAW 264.7 macrophages. Application of a chemically standardized jujube water extract in cultured RAW 264.7 cells for 24h stimulated the expressions of HO-1, biliverdin reductase A, biliverdin reductase B, and ferroportin in a concentration-dependent manner, having the maximal responses from twofolds to threefolds. A plasmid containing anti-oxidant response element, a regulator for HO-1 transcription, was transfected into RAW 264.7 cells. Application of jujube water extract onto the transfected macrophages stimulated the anti-oxidant response element-mediated transcriptional activity by twofolds. These results supported the potential capacity of jujube by regulating expressions of heme iron recycling genes in cultured macrophages. Copyright (c) 2015 John Wiley & Sons, Ltd.
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