期刊
JOURNAL OF RHEUMATOLOGY
卷 35, 期 12, 页码 2355-2358出版社
J RHEUMATOL PUBL CO
DOI: 10.3899/jrheum.080175
关键词
SYSTEMIC LUPUS ERYTHEMATOSUS; C-REACTIVE PROTEIN; DISEASE ACTIVITY; DISEASE DAMAGE
类别
资金
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [P01-AR49084]
- General Clinical Research Centers [M01-RR02558 (UTH-HSC), M01-RR00032 (UAB)]
- National Center for Research Resources (NCRR/NIH) RCMI Clinical Research Infrastructure Initiative (RCRII) award [IP20 RR11126 (UPR-MSC)]
- Bristol-Myers Squibb Company (UPR-MSC)
Objective. To determine whether C-reactive protein (CRP) measured by a high sensitivity (hs) assay is 11 Surrogate marker of disease activity and damage in systemic lupus erythematosus (SLE). Methods. Five hundred eighty-eight patients with SLE participating in a multiethnic cohort (Hispanic, African American, and Caucasian) were studied. Disease activity was measured with the Systemic Lupus Activity Measure-Revised (SLAM-R) and damage with the Systemic Lupus International Collaborating Clinics (SLICC) Damage Index (SDI). hs-CRP was measured by immunometric assay. Disease activity and hs-CRP were measured at enrollment and damage accrual at last visit. The association of hs-CRP with the SLAM-R and SDI was examined by univariable (Pearson's correlation) and multivariable (linear regression) analyses. The association of hs-CRP and each individual domain of the SLAM-R and SDI was examined by Spearman's correlation. Results. hs-CRP was associated with the SLAM-R in the Univariable (r = 0.35, p < 0.001) and multivariable (t = 7.11, coefficient beta = 0.27, p < 0.001) analyses. It also correlated with the constitutional, eye, pulmonary, gastrointestinal, neuromotor, and laboratory domains of the SLAM-R. hs-CRP was associated with the SDI (r = 0.12, p = 0.004) in the univariable analysis but not in the multivariable analysis. When the individual domains of the SDI were analyzed, hs-CRP correlated with the renal, pulmonary, cardiovascular, musculoskeletal, and diabetes domains. Conclusion. hs-CRP was associated with disease activity but not with overall damage accrual; however, it correlated with specific domains of the damage index. hs-CRP may be useful to monitor the course of the disease and predict its intermediate outcome, but longitudinal studies with serial hs-CRP measurements are necessary to define its clinical value. (First Release Nov 1 2008; J Rheumatol 2008;35:2355-8; doi: 10.3899/jrheum.080175)
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