4.5 Article

Rheology of magnetic alginate hydrogels

期刊

JOURNAL OF RHEOLOGY
卷 62, 期 5, 页码 1083-1096

出版社

JOURNAL RHEOLOGY AMER INST PHYSICS
DOI: 10.1122/1.5028137

关键词

-

资金

  1. Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica, MINECO, Spain [FIS2013-41821-R]
  2. ERDF, European Union [FIS2013-41821-R]
  3. Ministerio de Economia, Industria y Competitividad, MINECO [F152017-85954-R]
  4. Agencia Estatal de Investigacion, AEI, Spain [F152017-85954-R]
  5. Fondo Europeo de Desarrollo Regional, FEDER, European Union
  6. Ministry of Education and Science of the Russian Federation [02.A03.21.0006, 3.1438.2017/4.6, 3.5214.2017/6.7]
  7. Russian Fund of Basic Researches [18-08-00178]
  8. French government [ANR-15-IDEX-01]

向作者/读者索取更多资源

Magnetic hydrogels are becoming increasingly in demand for technical and biomedical applications, especially for tissue engineering purposes. Among them, alginate-based magnetic hydrogels emerge as one of the preferred formulations, due to the abundance, low cost, and biocompatibility of alginate polymers. However, their relatively slow gelation kinetics provokes strong particle settling, resulting in nonhomogeneous magnetic hydrogels. Here, we study magnetic hydrogels prepared by a novel two-step protocol that allows obtaining macroscopically homogeneous systems, consisting of magnetic microparticles embedded within the alginate network. We describe a comprehensive characterization (morphology, microstructure, and mechanical properties under shear stresses) of the resulting magnetic hydrogels. We pay special attention to the effects of particle volume fraction (up to 0.33) and strength of the magnetic field on the viscoelastic properties of the magnetic hydrogels. Our results indicate that magnetic hydrogels are strongly strengthened against shear stresses as magnetic particle concentration and applied field intensity increase. Finally, we report an adaptation of the two-step protocol for the injection of the magnetic hydrogels that might be adequate for implementation in vivo. Interestingly, injected magnetic hydrogels present similar morphology and mechanical properties to noninjected hydrogels. To conclude, we report magnetic alginate hydrogels with adequate homogeneity and injectability character. These characteristics, together with the broad range of their mechanical properties, make them perfect candidates for cutting-edge technology. (C) 2018 The Society of Rheology.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据