期刊
PHYTOTHERAPY RESEARCH
卷 29, 期 12, 页码 1917-1925出版社
WILEY
DOI: 10.1002/ptr.5484
关键词
camphor; dermal fibroblast; proliferation; antiaging; ERK; ROS
资金
- Ministry of Knowledge Economy (MKE)
- Korea Institute for Advancement of Technology (KIAT)
- Jeju Leading Industry Office through the Leading Industry Development for Economic Region
Camphor ((1R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one), a bicyclic monoterpene, is one of the major constituents of essential oils fromvarious herbs such as rosemary, lavender, and sage. In this study, we investigated the beneficial effects of camphor as a botanical ingredient in cosmetics. Camphor induced the proliferation of human primary dermal fibroblasts in a dose-dependent manner via the PI3K/AKT and ERK signaling pathways. Camphor attenuated the elevation of senescence associated with beta-galactosidase (SA-beta-gal) activity. Elastase activity decreased, while the total amount of collagen increased, in a dose-and time-dependent manner in human primary dermal fibroblasts treated with camphor. Camphor induced the expression of collagen IA, collagen IIIA, collagen IVA, and elastin in human primary dermal fibroblasts. In addition, posttreatment with 26 and 52 mM camphor for 2 weeks led to a significant reduction in the expression of MMP1 but increases in the expression of collagen IA, IIIA, and elastin in mouse skin exposed to UV for 4 weeks. These posttreatments also reduced the depths of the epidermis and subcutaneous fat layer in UV-exposed mouse skin. Taken together, these findings suggest camphor to be a potent wound healing and antiwrinkle agent with considerable potential for use in cosmeceuticals. Copyright (C) 2015 John Wiley & Sons, Ltd.
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