期刊
PHYTOTHERAPY RESEARCH
卷 29, 期 8, 页码 1259-1264出版社
WILEY
DOI: 10.1002/ptr.5369
关键词
Rheum palmatum L; Aconitum carmichaelii Debx; rhubarb anthraquinones; compatibility; comparative pharmacokinetics
资金
- National Natural Science Foundation of China [81373943]
- National Basic Research Program of China (973 program) [2011BAI13B05, 2012CB723502]
- Sichuan Youth Science and Technology Foundation [2013JQ0018]
- Sichuan Provincial Science and Technology Department of Youth Science and Technology Innovation Research Team Program-Sichuan Province on Pharmacology of TCM Science and Technology Innovation Youth Team [2014TD0007]
- Chengdu University of Traditional Chinese Medicine Science and Technology Development Fund [ZRMS201339]
Rhei Radix et Rhizoma was one of the commonly used traditional Chinese medicines, and the compatibility of Rhei Radix et Rhizoma and Aconiti Lateralis Radix Praeparata was the basic herb pair applied in many Chinese traditional prescription. Rhubarb anthraquinones were the main bioactive materials of Rhei Radix et Rhizoma. To elucidate the compatibility of Rhei Radix et Rhizoma and Aconiti Lateralis Radix Praeparata, the pharmacokinetics of rhubarb anthraquinones as the main marker constituents were investigated. In the present study, pharmacokinetic differences of rhubarb anthraquinones were detected after oral administration of extract of Rheum palmatum L. and compatibility with Aconitum carmichaelii Debx. After oral administration, no difference of peak time can be found for anthraquinones between rhubarb group and compatibility group. But C-max and area under the curve of aloe-emodin, emodin and chrysophanol in compatibility group were significantly higher than that in rhubarb group. Although the C-max of rhein in compatibility group was much lower than that in rhubarb group, the area under the curve value was similar in two groups. The clearance and t(1/2) of rhubarb anthraquinone were also changed after compatibility. The change of pharmacokinetics characteristics of rhubarb anthraquinone after compatibility may be caused by the drug-drug interaction medicated by chemical reaction and cytochromes P450. Copyright (c) 2015 John Wiley & Sons, Ltd.
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