期刊
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 104, 期 -, 页码 43-48出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jri.2014.05.003
关键词
Epigenetics; Immune development; Immune function; Immune disease; DNA methylation
Epigenetic mechanisms such as DNA methylation, histone modification, and micro RNA signaling regulate the activity of the genome. Virtually all aspects of immunity involve some level of epigenetic regulation, whether it be host defense or in mediating tolerance. These processes are critically important in mediating dynamic responses to the environment over the life course of the individual, yet we are only just beginning to understand how dysregulation in these pathways may play a role in immune disease. Here, we give a brief chronological overview of epigenetic processes during immune development in health and disease. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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