期刊
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 93, 期 1, 页码 58-63出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jri.2011.12.001
关键词
Endometrium; IVF; CD163; Macrophages; Adenomyosis
Adenomyosis, a condition usually associated with multiparity, is not generally seen as a cause of infertility. However, recent studies have reported a reduction in IVF implantation rates and a link with miscarriage, suggesting that adenomyosis may interfere with successful implantation. To investigate this hypothesis, the clinical records and laboratory results, which routinely include immunohistochemical examination of a late luteal phase endometrial biopsy for leukocytes, were retrospectively reviewed for 64 women with implantation failure and who previously had been screened for the presence of adenomyosis by pelvic MRI. The presence of either diffuse or adenomyoma type of adenomyosis was associated with a marked increase (p = 0.004) in the density of macrophages and natural killer cells in the endometrial stroma, compared to those women with mild focal adenomyosis or no disease. These findings point to an immunological mechanism by which adenomyosis might interfere with successful embryo implantation. Crown Copyright (C) 2012 Published by Elsevier Ireland Ltd. All rights reserved.
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