期刊
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 93, 期 1, 页码 52-57出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jri.2011.11.001
关键词
hCG; Familial hCG Syndrome
资金
- Church and Dwight Co. Inc., a manufacturer of home pregnancy tests
- Quest Diagnostics Inc., the largest clinical laboratory in the US
An explanation is needed for why some men and women show positive in hCG screening tests when they are not pregnant, do not have cancer and are otherwise asymptomatic. In this study, a total of 10 families comprising 30 persons with a history of positive hCG tests were investigated. Total hCG was measured in serum and urine samples using the Siemens Immulite hCG test. Total hCG, C-terminal peptide determinant, and hCG beta were measured in 96 well plate assays. Twenty-four of 30 family members produced only hCG beta, and hCG or hCG beta missing the beta-subunit C-terminal peptide, two rarely detected hCG degradation products as the only source of hCG immunoreactivity. In every one of the 10 families, hCG related molecules were detected first in one member and then later detected in other family members. In 8 of 10 families, all members produced comparable hCG concentration (Cases 1-8). All of the 10 original family members investigated were otherwise asymptomatic, and tested negative in ordered head and pelvis MRI scans and CT chest cancer tests. None had been administered hCG for dietary, anabolic or fertility reasons. Therefore Familial hCG Syndrome, a genetic defect, was indicated in each of the 10 families. In these cases of Familial hCG Syndrome only biologically inactive variants of hCG were detected. It is inferred that in Familial hCG Syndrome, hCG gene expression does not interfere with fertility. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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