期刊
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 96, 期 1-2, 页码 68-78出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jri.2012.07.006
关键词
Preterm birth; Race; Amniotic fluid; Infection; Genital mycoplasma
资金
- NIH [1R03HD067446-01]
Spontaneous preterm birth (PTB) and preterm prelabor rupture of membranes (pPROM) occur more frequently in African-American women than in other racial groups. This may be due to an enhanced inflammatory response to pathogens associated with the condition. It is also possible that amniotic fluid (AF) has different immunomodulatory properties in African-American women that increase their risk of PTB and pPROM. To test this, we cultured fetal membranes from European-American and African-American women with sterile medium (control), Escherichia coli, Gardnerella vaginalis, Group B streptococci (GBS), Polyporphorans gingivalis, Mycoplasma hominis, Ureaplasma urealyticum or Ureaplasma parvum in the presence and absence of 50% autologous AF. Cytokine concentrations were quantified in the conditioned medium. All bacterial species increased IL-8 production. IL-1 beta and TNF-alpha production were stimulated by LPS, E. coli, and G. vaginalis compared with control, but responses to Group B streptococci and P. gingivalis were limited to IL-1 beta and TNF-alpha respectively. Genital mycoplasmas stimulated TNF-alpha and IL-10 but had no effect on IL-1 beta production. African-Americans had twice the IL-1 beta response to E. coli as European-Americans (P=0.031). Conversely, European-Americans produced more IL-8 in response to LPS than African-Americans (P=0.026). AF had both pro- and anti-inflammatory properties that varied between races and pathogens. These results suggest that the host response to fetal membrane infections is complex and not generalizable. Interventions to prevent PTB and pPROM may need to be customized based on a patient's race, type of bacterial infection and factors in her AF. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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