期刊
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 85, 期 1, 页码 71-75出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jri.2010.01.006
关键词
Pregnancy; T helper; Cytokines; Abortion; Immune tolerance; Rejection
The conceptus is considered a semi-allograft because of the presence of paternal HLA-C molecules. These alloantigens can be processed by maternal antigen presenting cells, which present them to specific maternal CD4+ T cells. After activation, the maternal CD4+ T cells can become effector decidual CD4+ T cells, which are able to release various cytokines. Th1-type cytokines (IFN gamma) that promote allograft rejection may compromise pregnancy, whereas the Th2-type cytokines (IL-4, IL-10) that inhibit Th1 responses, promote allograft tolerance and therefore may improve fetal survival. A collaborative interaction between the decidual natural regulatory T cells, CD4+ CD25+ Foxp3 T cells and NKT cells in preventing fetal allograft rejection is suggested. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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