Malnutrition-Inflammation Score is Associated With Handgrip Strength in Nondialysis-Dependent Chronic Kidney Disease Patients

Objective: The malnutrition-inflammation score (MIS) is a nutritional scoring system that has been associated with muscle strength among dialysis patients. We aimed to test whether MIS is able to predict muscle strength in nondialysis-dependent chronic kidney disease (NDD-CKD) individuals. Design and Methods: This was a cross-sectional study conducted at the Dante Pazzanese Institute of Cardiology, Hypertension, and Nephrology Division outpatient clinic. We evaluated 190 patients with NDD-CKD stages 2-5 (median 59.5 [interquartile range 51.4-66.9] years; 64% men). MIS was calculated without computing dialysis vintage to the scoring. HGS was assessed in the dominant arm. Anthropometric, laboratory, and body composition parameters were recorded. Results: A strong negative correlation was found between HGS and MIS (r = -0.42; P <= .001) in univariate analysis. In multivariate regressions, adjustment for age, sex, diabetes, glomerular filtration rate, body cell mass, and C-reactive protein did not materially diminish these relationships. Conclusions: MIS shares strong links with objective measures of muscle strength in NDD-CKD patients. (C) 2013 by the National Kidney Foundation, Inc. All rights reserved.