期刊
PHYTOMEDICINE
卷 22, 期 1, 页码 49-51出版社
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2014.11.001
关键词
Aldose reductase; Mangostin; Garcinia mangostana; Xanthone; Diabetic complications
资金
- research project for International Research Collaboration and Scientific Publication, Directorate General of Higher Education, Ministry of Education and Culture, Indonesia
We investigated aldose reductase inhibition of Garcinia mangostana Linn. from Indonesia. Dichloromethane extract of the root bark of this tree was found to demonstrate an IC50 value of 11.98 mu g/ml for human aldose reductase in vitro. From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors. We discovered 3-isomangostin to be most potent against aldose reductase, with an IC50 of 3.48 mu M. (C) 2015 Elsevier GmbH. All rights reserved.
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