期刊
JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT
卷 49, 期 3, 页码 373-380出版社
JOURNAL REHAB RES & DEV
DOI: 10.1682/JRRD.2011.04.0076
关键词
body composition; growth hormone; IGF-1; insulin-like growth factor; level of injury; Modified Ashworth Scale; MRI; rehabilitation; SCI; skeletal muscle; spasticity
The major objectives of this cross-sectional study were to (1) measure insulin-like growth factor-1 (IGF-1) in individuals with complete spinal cord injury (SCI) and spasticity and (2) determine the relationships between IGF-1 and cross-sectional areas (CSAs) of thigh skeletal muscle groups. Eight individuals with motor complete SCI underwent magnetic resonance imaging to measure the CSA of the whole thigh, knee extensor, and knee flexor skeletal muscle groups and dual-emission X-ray absorptiometry to measure fat-free mass. After participants fasted for 12 h, we measured their IGF-1 levels and determined spasticity using the Modified Ashworth Scale (MAS). Spearman rho correlations were used to test for the relationships among the tested variables, and independent t-tests were used to determine the difference in plasma IGF-1. Plasma IGF-1 was 44% greater in those with MAS scores of 2 or higher (p < 0.05). Plasma IGF-1 was positively related to knee extensor skeletal muscle CSA (r = 0.83, p < 0.01). IGF-1 was strongly related to knee extensor and flexor spasticity (r = 0.88,p < 0.004). The findings suggest that IGF-1 is greater in SCI individuals with increased spasticity, and this may explain the strong positive relationships that were noted between spasticity and skeletal muscle CSA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据