期刊
PHYTOCHEMISTRY LETTERS
卷 12, 期 -, 页码 113-118出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2015.03.006
关键词
Sansevieria cylindrica; Dracaenaceae; Steroidal saponin; Homoisoflavanone; Cytotoxicity; Antioxidant
资金
- National Research Centre
Phytochemical study on the methanolic extract of Sansevieria cylindrica aerial parts lead to the isolation, characterization and structure elucidation of a new steroidal saponin, 1 beta-hydroxy-kryptogenin-1-O-alpha-L- rhamnopyranosyl-(1 -> 2)-alpha-L-arabinopyranoside (1), a new homoisoflavanone, (3S)-3,7-dihydroxy-8-methoxy-3-(3',4'-methylenedioxybenzyl) chroman-4-one (2) and the known saponin alliospiroside A (3). To the best of our knowledge, the genin 1 beta-hydroxy-kryptogenin is reported here for the first time. The structures of the new compounds were determined by UV, IR, EIMS, HRESIMS together with 1D (H-1 and C-13) and 2D (HSQC and HMBC) NMR spectral analysis. The isolated compounds 1-3 were tested for their radical scavenging activity (DPPH). Compound 2 exhibited activity compared to that of ascorbic acid as a standard. The cytotoxicity of the isolated compounds and the standard doxorubicin was tested against the three human tumor cell lines HT116, MCF-7 and PC-3. The results showed that the isolated compounds were inactive. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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