期刊
PHYTOCHEMISTRY LETTERS
卷 12, 期 -, 页码 182-185出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2015.03.017
关键词
Indole-diterpenoids; Marine algal-derived fungus; Polysiphonia scopulorum var. villum; Aspergillus nidulans; Cytotoxic against brine shrimp; Antimicrobial activity
资金
- Natural Science Foundation of China [31330009]
- Ministry of Science and Technology of China [2010CB833802]
Two new compounds, including a chlorinated indole-diterpenoid 19-hydroxypenitrem A (1) and its dechlorinated derivative 19-hydroxypenitrem E (2), along with two known congeners (3 and 4), were isolated and identified from the cultures of Aspergillus nidulans EN-330, an endophytic fungus obtained from the marine red alga Polysiphonia scopulorum var. villum. Their structures and absolute configurations were assigned on the basis of 1D and 2D NMR and CD experiments. Compounds 1-4 exhibited cytotoxic activity against brine shrimp with LD50 values of 3.2, 4.6, 1.7, and 8.7 mu M, respectively. Besides, the chlorinated 19-hydroxypenitrem A (1) showed antimicrobial activity against four human-and aqua-pathogens. Preliminary SAR study revealed that the Cl-substitution at C-6 enhanced the cytotoxic activity against brine shrimp and antimicrobial activity, while the 19-OH substitution suppressed the activity. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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