期刊
PHYTOCHEMISTRY LETTERS
卷 11, 期 -, 页码 28-31出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2014.10.028
关键词
Clerodane; Diterpenes; Antiplasmodial; Polyalthia longifolia; Bisclerodane imide
Along with two known compounds (1 and 2), four new clerodane diterpenes were isolated and identified from the stem bark of Polyalthia longifolia: cleroda-3-ene pyrrole-15,16-dione (3), cleroda-3-ene, pyrrolidine-15,16-dione (4), cleroda-3,13(14) E-diene-15,16-diamide (5), and cleroda-3-ene-15, 16-diamide (6). Their structures were elucidated by combinations of NMR, MS and IR. Using the WHO Mark III Microtest assay, the isolated compounds were evaluated for their antiplasmodial effects. They showed antiplasmodial effects, with IC(50)s ranging from 4.5 to 213.8 mu M. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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