期刊
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
卷 33, 期 3, 页码 139-143出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10799893.2013.763828
关键词
Chaperone; G protein alpha; guanine nucleotide exchange factor (GEF)
资金
- NIGMS NIH HHS [R01 GM088242, GM08824] Funding Source: Medline
Resistance to inhibitors of cholinesterase 8 proteins (Ric-8A and Ric-8B) collectively bind the four classes of heterotrimeric G protein alpha subunits. Ric-8A and Ric-8B act as non-receptor guanine nucleotide exchange factors (GEFs) toward the G alpha subunits that each binds in vitro and seemingly regulate diverse G protein signaling systems in cells. Combined evidence from worm, fly and mammalian systems has shown that Ric-8 proteins are required to maintain proper cellular abundances of G proteins. Ric-8 proteins support G protein levels by serving as molecular chaperones that promote G alpha subunit biosynthesis. In this review, the evidence that Ric-8 proteins act as non-receptor GEF activators of G proteins in signal transduction contexts will be weighed against the evidence supporting the molecular chaperoning function of Ric-8 in promoting G protein abundance. I will conclude by suggesting that Ric-8 proteins may act in either capacity in specific contexts. The field awaits additional experimentation to delineate the putative multi-functionality of Ric-8 towards G proteins in cells.
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