期刊
PHYTOCHEMISTRY
卷 116, 期 -, 页码 337-348出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2015.03.014
关键词
Salvia grandifolia; Labiatae; Isolation; Structural elucidation; Biological activity; Absolute configuration; Vasorelaxant effect; Diterpenoid
资金
- Fundamental Research Funds for the Central Universities - China [2013RC03]
- National Natural Science Foundation of China - China [21302227]
A phytochemical investigation of root extracts of Salvia grandifolia led to isolation of six previously unreported diterpenoids, grandifolias A-F, along with eight known compounds. The structures of grandifolias A-F were primarily established by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. Their absolute configurations were assigned by their calculated and experimental electronic circular dichroism spectra or by X-ray diffraction analysis. All of the diterpenoids were evaluated for their vasorelaxant effects. Grandifolia B and isograndifoliol both exhibited dose-dependent vasorelaxant effects on rat aortic rings, preconstricted by KCl or norepinephrine, with EC50 values of 36.36-74.51 mu g/mL. (C) 2015 Elsevier Ltd. All rights reserved.
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