期刊
PHYTOCHEMISTRY
卷 109, 期 -, 页码 147-153出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2014.10.012
关键词
Withanolide; Physalis coztomatl; Solanaceae; Physacoztolide; Structure revision; Coagulansin A
资金
- Kansas Bioscience Authority (KBA) [IND 0061464]
- Center for Heartland Plant Innovations (HPI)
- KU [2506014-910/099]
- National Science Foundation (NSF) MRI [CHE-0923449]
- NSF MRI [0320648]
- NIH Shared Instrumentation [S10RR024664, S10RR014767]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0320648] Funding Source: National Science Foundation
Six withanolides (1-6), as well as two known withanolides (physachenolide D 7 and withanoside VI 8), were isolated from the aerial parts of Physalis coztomatl (Solanaceae). Structural elucidations of 1-6 were achieved through 2D NMR and other spectroscopic techniques, while the structure of 1 was confirmed by X-ray crystallographic analysis. In addition, the stereochemical orientation of the 17-hydroxy group in withanolides was discussed in relation to C-13 NMR shifts of C-12, 13, 14 and 16. Such analysis established that coagulansin A contains a 17 alpha-hydroxy moiety rather than the reported 17 beta-hydroxy functionality, and has been revised accordingly. (C) 2014 Elsevier Ltd. All rights reserved.
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