期刊
JOURNAL OF RAMAN SPECTROSCOPY
卷 44, 期 10, 页码 1440-1445出版社
WILEY-BLACKWELL
DOI: 10.1002/jrs.4286
关键词
asbestos; erionite; crocidolite; Raman spectroscopy; malignant mesothelioma
类别
资金
- Ministero dell'Istruzione dell'Universita e della Ricerca
- NCI R01
- Mesothelioma Applied Research Foundation
- Riviera United-4 a CURE
- Hawaii Community Foundation
- NCI P01
Exposure to asbestos or erionite is associated with malignant mesothelioma (MM) and other diseases. Micro-Raman spectroscopy and Variable Pressure Scanning Electron Microscopy/Energy Dispersive Spectroscopy were used to identify mineral fibers in histological sections of various tissues taken from mice injected with crocidolite asbestos and erionite fibers. Routine diagnostic histopathological slides of biopsies from erionite-exposed MM patients from Turkey were also analyzed. We show here that micro-Raman spectroscopy easily permits the recording of distinct Raman patterns of both crocidolite and erionite fibers, in both murine tissues and in human biopsies. The described findings provide a new powerful and non-destructive tool to determine the type of fiber exposure in patients with MM and other mineral fiber-associated diseases. Copyright (c) 2013 John Wiley & Sons, Ltd.
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