期刊
JOURNAL OF RAMAN SPECTROSCOPY
卷 43, 期 7, 页码 817-827出版社
WILEY
DOI: 10.1002/jrs.3100
关键词
SERS; TERS; cells; nanoparticles; nanopipettes; carbon nanotubes
类别
资金
- W. M. Keck Foundation
Surface-enhanced Raman spectroscopy (SERS) is a promising and powerful label free technique for high resolution analysis of single cells. For intracellular analysis, there is a need for SERS-active nanoprobes that are minimally invasive to cells, do not affect cell viability, and provide reproducible signals. This work reviews the state-of-the-art tools currently available for intracellular SERS. Various types of SERS probes are considered, including colloidal gold and silver nanoparticles, metallized optical fibers, and tip-enhanced Raman probes. We also discuss recently developed SERS-active nanopipettes implemented on the basis of pulled glass microcapillaries. Finally, the critical aspects of selecting an optimal SERS nanoprobe for single-cell analysis depending on a particular application are summarized. Copyright (c) 2012 John Wiley & Sons, Ltd.
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