期刊
JOURNAL OF PUBLIC HEALTH
卷 41, 期 3, 页码 494-501出版社
OXFORD UNIV PRESS
DOI: 10.1093/pubmed/fdy137
关键词
ambient air pollution; birth defects; NO2; PM10; SO2
资金
- Project of birth defect control and prevention in Shaanxi [Sxwsjswzfcght2016-013]
- National Natural Science Foundation of China [81230016]
Background The aim of this study was to investigate an association between birth defects and exposure to sulfur dioxide (SO2), nitrogen dioxide (NO2) and particles <= 10 mu m in an aerodynamic diameter (PM10) during early pregnancy in Xi'an, China. Methods Birth defect data were from the Birth Defects Monitoring System of Xi'an, and data on ambient air pollutants during 2010-15 were from the Xi'an Environmental Protection Bureau. A generalized additive model (GAM) was used to investigate the relationship between birth defects and ambient air pollutants. Results Among the 8865 cases with birth defects analyzed, the overall incidence of birth defects was 117.33 per 10 000 infants. Ambient air pollutant exposure during the first trimester increased the risk of birth defects by 10.3% per 10 mu g/m(3) increment of NO2 and 3.4% per 10 mu g/m(3) increment of PM10. No significant association was found between birth defects and SO2. Moreover, NO2 increased risk of neural tube defects, congenital heart disease, congenital polydactyly, cleft palate, digestive system abnormalities and gastroschisis, and PM10 was associated with congenital heart disease and cleft lip with or without cleft palate. Conclusions Chinese women should avoid exposure to high levels of NO2 and PM10 during the first 3 months of pregnancy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据