期刊
JOURNAL OF PSYCHOSOMATIC RESEARCH
卷 77, 期 4, 页码 302-308出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychores.2014.07.002
关键词
Asthma; Odors; Fragrances; Risk perception; Exhaled nitric oxide; Nocebo effect
类别
资金
- NIH-NIDCD [RO1 DC 06760]
Objective: Fragrances and strong odors have been characterized as putative triggers that may exacerbate asthma symptoms and many asthmatics readily avoid odors and fragranced products. However, the mechanism by which exposure to pure, non-irritating odorants can elicit an adverse reaction in asthmatic patients is still unclear and may involve both physiological and psychological processes. The aim of this study was to investigate how beliefs about an odor's relationship to asthmatic symptoms could affect the physiological and psychological responses of asthmatics. Methods: Asthmatics classified as 'moderate-persistent', according to NIH criteria, were exposed for 15 min to a fragrance which was described either as eliciting or alleviating asthma symptoms. During exposure, participants were asked to rate odor intensity, perceived irritation and subjective annoyance while physiological parameters such as electrocardiogram, respiratory rate, and end tidal carbon dioxide (etCO(2)) were recorded. Before, immediately after, and at 2 and 24 h post-exposure, participants were required to subjectively assess their asthma symptom status using a standardized questionnaire. We also measured asthma status at each of those time points using objective parameters of broncho-constriction (spirometry) and measures of airway inflammation (exhaled nitric oxide, FeNO). Results: Predictably, manipulations of perceived risk altered both the quality ratings of the fragrance as well as the reported levels of asthma symptoms. Perceived risk also modulated the inflammatory airway response. Conclusions: Expectations elicited by smelling a perceived harmful odor may affect airway physiology and impact asthma exacerbations. (C) 2014 Elsevier Inc. All rights reserved.
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