期刊
JOURNAL OF PSYCHOSOMATIC RESEARCH
卷 74, 期 4, 页码 340-345出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychores.2012.12.011
关键词
General population; Posttraumatic stress disorder; Trauma experience; Type 2 diabetes; Prediabetes
类别
资金
- Helmholtz Zentrum Munchen, German Research Center for Environmental Health (GmbH)
- German Federal Ministry of Education and Research (BMBF)
- State of Bavaria
- German Federal Ministry of Education and Research (BMBF) in the context of the Competence Network for Diabetes Mellitus, subproject Diabetes and Mental Aspects Network (DIAMANT) [01GI1110E]
Objectives: To evaluate the association of posttraumatic stress disorder (PTSD) with type 2 diabetes (T2D) or prediabetes in a large population-based sample. Methods: In 2970 subjects (aged 32-81 years) drawn from the population-based cross-sectional study KORA F4 from the Augsburg region (Southern Germany) a PTSD screening was performed employing the. Posttraumatic Diagnostic Scale, the Impact of Event Scale, and interview data. The exposure variable PTSD was sub-classified into partial and full PTSD and additionally in subjects with traumatic event but no PTSD to The exposure variable PTSD was classified into (1) no traumatic event (2) traumatic event, but no PTSD, (3) partial PTSD, (4) full PTSD. A total of 50 (1.7%) subjects qualified for full PTSD, whereas 261 (8.8%) qualified for partial PTSD. A total of 333 subjects (11.2%) suffered from T2D and 498 (16.8%) from prediabetes as assessed by an oral glucose tolerance test and physicians' validation. The associations of PTSD with T2D and prediabetes were estimated by multinomial logistic regression analyses with adjustments for sociodemographic characteristics, metabolic risk factors or psychopathological conditions. Results: In the model adjusted for sociodemographic characteristics and metabolic risk factors, full PTSD was significantly associated with T2D (OR: 3.90,95% Cl: 1.61-9.45,p=0.003) compared to subjects with no traumatic event. Significance remained after additional adjustment for other psychopathological conditions (OR: 3.56, 95% Cl: 1.43-8.85, p=0.006). Regarding prediabetes, no significant associations were observed. Conclusions: Suffering from PTSD might activate chronic stress symptoms and trigger physiological mechanisms leading to T2D. Prospective studies are needed to investigate temporal and causal relationships between PTSD and T2D. (C) 2013 Elsevier Inc. All rights reserved.
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