期刊
JOURNAL OF PSYCHOPHARMACOLOGY
卷 26, 期 1, 页码 40-55出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0269881111400651
关键词
Amygdala; anxiety; bed nucleus of the stria terminalis; cannabidiol; endocannabinoid; hippocampus; medial prefrontal cortex; periaqueductal gray
资金
- FAPEMIG
- FAPESP
- CNPq
- CAPES
Administration of Cannabis sativa derivatives causes anxiolytic or anxiogenic effects in humans and laboratory animals, depending on the specific compound and dosage used. In agreement with these findings, several studies in the last decade have indicated that the endocannabinoid system modulates neuronal activity in areas involved in defensive responses. The mechanisms of these effects, however, are still not clear. The present review summarizes recent data suggesting that they involve modulation of glutamate and GABA-mediated neurotransmission in brain sites such as the medial prefrontal cortex, amygdaloid complex, bed nucleus of the stria terminalis, hippocampus and dorsal periaqueductal gray. Moreover, we also discuss results indicating that, in these regions, the endocannabinoid system could be particularly engaged by highly stressful situations.
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