期刊
JOURNAL OF PSYCHOPHARMACOLOGY
卷 25, 期 11, 页码 1568-1572出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0269881110385600
关键词
Dopamine; nucleus accumbens; posttraumatic stress disorder; prefrontal cortex; psychostimulant
The objective of this paper is to describe three cases of combat-related posttraumatic stress disorder ( PTSD), largely refractory to standard medication treatment who responded well to psychostimulant treatment. Symptoms of PTSD potentially result from chronic, stress-induced dopaminergic dysfunction in the prefrontal cortex/basal ganglia system. Psychostimulants, by their relative propensity to enhance dopamine (DA) activity within these brain regions, may have particular value in targeting this dysfunction. Evidence of dopaminergic dysfunction following chronic stress is reviewed and possible mechanism of action of psychostimulants is explored. Psychostimulants appeared to be well tolerated and beneficial in the treatment of the cases of combat-related PTSD reported. General applicability of the use of psychostimulants in combat-and non-combat-related PTSD awaits further study. The potential implications of these findings in further delineating pathophysiology and treatment in PTSD deserve further exploration.
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