期刊
JOURNAL OF PSYCHOPHARMACOLOGY
卷 24, 期 8, 页码 1137-1141出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0269881110374782
关键词
Citalopram; enantiomers; escitalopram; eszopiclone; fluoxetine; zopiclone
资金
- Lundbeck UK
It is well known that many medicines are a mixture of two enantiomers, or mirror-image molecules. Two enantiomers occur when a molecule has a single chiral centre and the two mirror images, called S or L (left handed) and R or D (right handed), are usually found in equal amounts in the parent (racemic) mixture. While for many compounds used in clinical practice the active moiety is found in one of the two enantiomers with the other being seen as an unnecessary and redundant component of the racemic mixture, the difference between enantiomers can mean a difference between therapeutic and adverse effects, as well as in beneficial pharmacological effect and potency.
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