期刊
JOURNAL OF PSYCHOPHARMACOLOGY
卷 25, 期 2, 页码 274-279出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0269881109106925
关键词
BDNF; bipolar disorder; cannabidiol; mania; oxidative stress
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq-Brazil-554490/2005-6]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP -02/13197-2]
- Instituto Cerebro e Mente
- UNESC
- FAPESC
- THC-Pharm (Frankfurt, Germany)
- STI Pharmaceuticals Ltd, (Brentwood, UK)
- CNPq
- CAPES
- FAPESP
Cannabidiol (CBD), a Cannabis sativa constituent, may present a pharmacological profile similar to mood stabilizing drugs, in addition to anti-oxidative and neuroprotective properties. The present study aims to directly investigate the effects of CBD in an animal model of mania induced by D-amphetamine (D-AMPH). In the first model (reversal treatment), rats received saline or D-AMPH (2 mg/kg) once daily intraperitoneal (i.p.) for 14 days, and from the 8th to the 14th day, they were treated with saline or CBD (15, 30 or 60 mg/kg) i.p. twice a day. In the second model (prevention treatment), rats were pretreated with saline or CBD (15, 30, or 60 mg/kg) regime i.p. twice a day, and from the 8th to the 14th day, they also received saline or D-AMPH i.p. once daily. In the hippocampus CBD (15 mg/kg) reversed the D-AMPH-induced damage and increased (30 mg/kg) brain-derived neurotrophic factor (BDNF) expression. In the second experiment, CBD (30 or 60 mg/kg) prevented the D-AMPH-induced formation of carbonyl group in the prefrontal cortex. In the hippocampus and striatum the D-AMPH-induced damage was prevented by CBD (15, 30 or 60 mg/kg). At both treatments CBD did not present any effect against D-AMPH-induced hyperactivity. In conclusion, we could not observe effects on locomotion, but CBD protect against D-AMPH-induced oxidative protein damage and increased BDNF levels in the reversal model and these effects vary depending on the brain regions evaluated and doses of CBD administered.
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