期刊
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
卷 36, 期 2, 页码 78-86出版社
CMA-CANADIAN MEDICAL ASSOC
DOI: 10.1503/jpn.100057
关键词
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资金
- Australian National Health and Medical Research Council [509109]
- Melbourne Research Scholarship
- Stanley Medical Research Institute
- MBF
- National Health and Medical Research Council
- Beyond Blue
- Geelong Medical Research Foundation
- Bristol Myers Squibb
- Eli Lilly
- GlaxoSmithKline
- Organon
- Novartis
- Mayne Pharma
- Servier
- Janssen Cilag
- Astra Zeneca
- Wyeth
- Pfizer
There is an expanding field of research investigating the benefits of alternatives to current pharmacological therapies in psychiatry. N-acetylcysteine (NAG) is emerging as a useful agent in the treatment of psychiatric disorders. Like many therapies, the clinical origins of NAC are far removed from its current use in psychiatry. Whereas the mechanisms of NAG are only beginning to be understood, it is likely that NAG is exerting benefits beyond being a precursor to the antioxidant, glutathione, modulating glutamatergic, neurotropic and inflammatory pathways. This review outlines the current literature regarding the use of NAG in disorders including addiction, compulsive and grooming disorders, schizophrenia and bipolar disorder. N-acetylcysteine has shown promising results in populations with these disorders, including those in whom treatment efficacy has previously been limited. The therapeutic potential of this acetylated amino acid is beginning to emerge in the field of psychiatric research.
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