期刊
JOURNAL OF PSYCHIATRIC RESEARCH
卷 47, 期 8, 页码 1024-1031出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2013.03.020
关键词
Social phobia; Panic disorder; Faces; Amygdala; Connectivity
类别
资金
- Geestkracht program of the Netherlands Organisation for Health Research and Development (Zon-Mw) [10-000-1002]
- VU University Medical Center Amsterdam
- University Medical Center Groningen
- Leiden University Medical Center
- GGZ inGeest
- Arkin
- GGZ Rivierduinen
- Lentis
- GGZ Friesland
- GGZ Drenthe
- Scientific Institute for Quality of Healthcare (IQ healthcare)
- Netherlands Institute for Health Services Research (NIVEL)
- Netherlands Institute of Mental Health and Addiction (Trimbos Institute)
Social phobia (SP) and panic disorder (PD) have been associated with aberrant amygdala responses to threat-related stimuli. The aim of the present study was to examine amygdala function and its connectivity with medial prefrontal cortex (mPFC) during emotional face perception in PD and SP, and the role of illness severity. Blood oxygen level dependent responses while perceiving emotional facial expressions were compared in 14 patients with PD, 17 patients with SP, 8 patients with comorbid PD and SP, and 16 healthy controls. We found that PD, but not SP, was associated with amygdala and lingual gyrus hypoactivation during perception of angry, fearful, happy and neutral faces, compared to healthy participants. No significant effect of PD and SP diagnoses was found on amygdala-mPFC connectivity. A positive correlation of anxiety symptom severity was found on amygdala-dorsal anterior cingulate and dorsal mPFC connectivity during perception of fearful faces. Amygdala hypoactivation suggests reduced responsiveness to positive and negative emotional faces in PD. Symptom severity, but not the presence of PD and SP diagnosis per se, explains most of the abnormalities in amygdala-mPFC connectivity during perception of fearful faces. (C) 2013 Elsevier Ltd. All rights reserved.
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