期刊
JOURNAL OF PSYCHIATRIC RESEARCH
卷 47, 期 4, 页码 425-437出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2012.11.007
关键词
Schizophrenia; mRNA; Expression; PBMCs; Immune; Inflammation
类别
资金
- Schizophrenia Research Institute
- Hunter Medical Research Institute
- Neurobehavioral Genetics Unit
- NSW Ministry of Health
- MC Ainsworth Research Fellowship in Epigenetics (MC)
- National Health and Medical Research Council of Australia [386500]
- Pratt Foundation
- Ramsay Health Care
- Viertel Charitable Foundation
Peripheral blood mononuclear cells (PBMCs) represent an accessible tissue source for gene expression profiling in schizophrenia that could provide insight into the molecular basis of the disorder. This study used the Illumina HT_12 microarray platform and quantitative real time PCR (QPCR) to perform mRNA expression profiling on 114 patients with schizophrenia or schizoaffective disorder and 80 non-psychiatric controls from the Australian Schizophrenia Research Bank (ASRB). Differential expression analysis revealed altered expression of 164 genes (59 up-regulated and 105 down-regulated) in the PBMCs from patients with schizophrenia compared to controls. Bioinformatic analysis indicated significant enrichment of differentially expressed genes known to be involved or associated with immune function and regulating the immune response. The differential expression of 6 genes, EIF2C2 (Ago 2), MEF2D, EVL, PI3, S100A12 and DEFA4 was confirmed by QPCR. Genome-wide expression analysis of PBMCs from individuals with schizophrenia was characterized by the alteration of genes with immune system function, supporting the hypothesis that the disorder has a significant immunological component in its etiology. (C) 2012 Elsevier Ltd. All rights reserved.
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