期刊
JOURNAL OF PSYCHIATRIC RESEARCH
卷 46, 期 7, 页码 940-945出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2012.04.010
关键词
Risk-taking; BART; COMT Val(158)Met; Dopamine; Adolescents
类别
资金
- US-NICHD [HD055885]
- National Institutes of Health
- Veteran's Administration
- Mohegan Sun Casino
- National Center for Responsible Gaming and its affiliated Institute for Research on Gambling Disorders
- Forest Laboratories pharmaceuticals
- [R01 DA018647-02S1]
- [RL1 AA017539]
- [P20 DA027844]
- [US-HD055885]
- [DA018730-04A1]
- [DA029445]
- [K23DA023143-01]
Although adolescents frequently engage in a variety of risky behaviors, much remains unknown about the specific etiologies of such tendencies. Candidate genetic variants, such as the COMT Val(158)Met polymorphism, may be related to risk-taking propensity, particularly as this variant is linked to functional enzymatic differences influencing dopamine function in regions including the prefrontal cortex. The present study aimed to examine the COMT Val(158)Met variant in relation to risk-taking propensity in a community sample of youth. As part of a larger longitudinal study on adolescent risk behaviors, 223 youths (average age 11.3 years) from the metropolitan Washington D.C. area completed a measure of risk-taking propensity, the Balloon Analog Risk Task-Youth Version (BART-Y), and provided saliva samples for DNA extraction and genotyping. Results indicate that females, but not males, who are carriers of the COMT (158)Met allele had higher risk-taking propensity scores on the BART-Y compared to Val homozygotes. Analyses were also conducted in the 111 European American participants, and results were consistent with those of the full sample analyses. This study represents the first investigation of a genetic substrate of risk-taking propensity, measured by a behavioral task, in youth. Results should be taken as quite preliminary, given the small sample. Implications are discussed. (C) 2012 Elsevier Ltd. All rights reserved.
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