期刊
JOURNAL OF PSYCHIATRIC RESEARCH
卷 44, 期 15, 页码 1069-1074出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2010.03.013
关键词
Single prolonged stress; Fear extinction; Glycine; Glycine transporter 1; Hippocampus; Posttraumatic stress disorder
类别
资金
- Ministry of Education Science and Culture of Japan
- Ministry of Health and Welfare of Japan
- Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology (JST)
Previous studies have demonstrated that rats subjected to single prolonged stress (SPS) exhibit posttraumatic stress disorder (PTSD)-like symptoms such as enhanced contextual fear in response to trauma related and trauma-unrelated events Furthermore we previously reported that upregulation of hippocampal glycine transporter 1 (GlyT-1) mRNA after context exposure could be the initial mechanism underlying impaired fear extinction in SPS rats To clarify the involvement of the hippocampal glycinergic system in impaired fear extinction in SPS rats we measured the time course of changes in the duration of freezing, and the hippocampal levels of Gly-T1 mRNA using contextual fear conditioning (FC) and extinction training We also used in vivo microdialysis to measure the concentration of extracellular glycine in the hippocampus during the time interval between FC and the first context exposure SPS rats exhibited increased and sustained contextual fear responses The enhanced contextual fear response in SPS rats was associated with a sustained increase in hippocampal levels of Gly-T1 mRNA after FC relative to sham rats and by a decrease in the extracellular glycine concentration GlyT-1 mRNA levels in rats that underwent repeated extinction training were significantly lower than in rats that did not undergo extinction training These findings indicate that reduced activity of the hippocampal glycinergic system could be closely involved in impaired fear extinction in SPS rats suggesting that activation of the glycinergic system by D-cycloserine or GlyT-1 inhibitors may ameliorate the impairment of fear extinction (C) 2010 Elsevier Ltd All rights reserved
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据