期刊
JOURNAL OF PSYCHIATRIC RESEARCH
卷 44, 期 2, 页码 106-111出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2009.05.005
关键词
Social defeat; Emotional stress; Acoustic startle
类别
资金
- American Psychological Association Minority Fellowship Program [MH18882]
- Facilitating Academic Careers in Engineering and Science Program at Emory University [0450303, I-66-606-63]
- NATIONAL CANCER INSTITUTE [U54CA118638] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [T32MH018882, P50MH058922] Funding Source: NIH RePORTER
- National Institute on Minority Health and Health Disparities [U54MD007588] Funding Source: NIH RePORTER
Individuals exposed to psychological stressors may experience a long-term resetting of behavioral and neuroendocrine aspects of their stress response so that they either hyper or hypo-respond to subsequent stressors. These effects of psychological or traumatic stressors may be mimicked in rats using the resident-intruder model of social defeat. The social defeat model has been characterized to model aspects of the physiology and behavior associated with anxiety and depression. The objective of this study was to determine if behaviors elicited following repeated social defeat can also reflect aspects of ethologically relevant stresses associated with existing post traumatic stress disorder (PTSD) models. Socially defeated rats displayed weight loss and an enhanced and prolonged response to acoustic startle which was displayed for up to 10 days following repeated social defeat. These data indicate that the severe stress of social defeat can produce physiologic and behavioral outcomes which may reflect aspects of traumatic psychosocial stress. (C) 2009 Elsevier Ltd. All rights reserved.
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