Carbon acquisition and accumulation in microalgae Chlamydomonas: Insights from omics approaches

Understanding the processes and mechanisms of carbon acquisition and accumulation in microalgae is fundamental to enhance the cellular capabilities aimed to environmental and industrial applications. The omics approaches have greatly contributed to expanding the knowledge on these carbon-related cellular responses, reporting large data sets on microalgae transcriptome, proteome and metabolome. This review emphasizes the advances made on Chlamydomonas exploration; however, some knowledge acquired from studying this model organism, may be extrapolated to close algae species. The large data sets available for this organism revealed the identity of a vast range of genes and proteins which are integrating carbon-related mechanisms. Nevertheless, these data sets have also highlighted the need for integrative analysis in order to fully explore the information enclosed. Here, some of the main results from omics approaches which may contribute to the understanding of carbon acquisition and accumulation in Chlamydomonas were reviewed and possible applications were discussed. Biological significance A number of important publications in the field of omics technologies have been published reporting studies of the model green microalga Chlamydomonas reinhardtii and related to microalgal biomass production. However, there are only few attempts to integrate these data. Publications showing the results from omics approaches, such as transcriptome, metabolome and proteome, focused in the study of mechanisms of carbon acquisition and accumulation in microalgae were reviewed. This review contributes to highlight the knowledge recently generated on such omics studies and it discusses how these results may be important for the advance of applied sciences, such as microalgae biotechnology. (C) 2013 Elsevier B.V. All rights reserved.