期刊
JOURNAL OF PROTEOMICS
卷 74, 期 11, 页码 2300-2312出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jprot.2011.05.032
关键词
Nitration; Tryptophan; Nitric oxide; Peroxynitrite; 3-NT; Nitrotryptophan
资金
- NIH [HL087062, HL046403, AG032195-01A1, GM073564-04S1]
Reactive nitrogen species are formed during a variety of disease states and have been shown to modify several amino acids on proteins. To date, the majority of research in this area has focused on the nitration of tyrosine residues to form 3-nitrotyrosine. However, emerging evidence suggests that another modification, nitration of tryptophan residues, to form nitrotryptophan (NO2-Trp), may also play a significant role in the biology of nitrosative stress. This review takes an in-depth look at NO2-Trp, presenting the current research about its formation, prevalence and biological significance, as well as the methods used to identify NO2-Trp-modified proteins. Although more research is needed to understand the full biological role of NO2-Trp, the data presented herein suggest a contribution to nitrosative stress-induced cell dysregulation and perhaps even in physiological cell processes. (C) 2011 Elsevier B.V. All rights reserved.
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