期刊
JOURNAL OF PROTEOMICS
卷 74, 期 12, 页码 2617-2631出版社
ELSEVIER
DOI: 10.1016/j.jprot.2011.03.032
关键词
Drug; Pharmaceuticals; Metabolite; MALDI; SIMS; NIMS; DESI; LAESI; Mass spectrometry; Imaging mass spectrometry (IMS); Mass spectrometric imaging (MSI)
资金
- National Science Foundation [CHE-0957784]
- National Institutes of Health [1R01DK071801]
- Alfred P. Sloan Research Fellowship
- Vilas Associate Award
- H. I. Romnes Faculty Fellowship
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [957784] Funding Source: National Science Foundation
Mass spectrometric imaging (MSI) is a powerful analytical technique that provides two-and three-dimensional spatial maps of multiple compounds in a single experiment. This technique has been routinely applied to protein, peptide, and lipid molecules with much less research reporting small molecule distributions, especially pharmaceutical drugs. This review's main focus is to provide readers with an up-to-date description of the substrates and compounds that have been analyzed for drug and metabolite composition using MSI technology. Additionally, ionization techniques, sample preparation, and instrumentation developments are discussed. (C) 2011 Elsevier B.V. All rights reserved.
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