期刊
JOURNAL OF PROTEOMICS
卷 73, 期 3, 页码 421-435出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jprot.2009.07.004
关键词
Red blood cell; Comparative proteomics; Membrane; Patho-physiology
Membrane proteomics offers unprecedented possibilities to compare protein expression in health and disease leading potentially to the identification of markers, of targets for therapeutics and to a better understanding of disease mechanisms. From transfusion medicine to infectious diseases, from cardiovascular affections to diabetes, comparative proteomics has made a contribution to the identification of proteins unique to RBCs of patients with specific illnesses shedding light on possible RBC markers for systemic diseases. In this review we will provide a short overview of some of the main achievements obtained by comparative proteomics in the field of RBC-related local and systemic diseases and suggest some additional areas of RBCs research to which comparative proteomics approaches could be fruitfully applied or extended in combination with biochemical techniques. (C) 2009 Elsevier B.V. All rights reserved.
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