期刊
JOURNAL OF PROTEOME RESEARCH
卷 14, 期 1, 页码 531-540出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr5007894
关键词
Nutrimetabolomics; Mediterranean diet; NMR; low-fat diet; olive oil; nuts
资金
- Spanish National Grants from Ministry of Economy and Competitiveness (MINECO)
- FEDER (Fondo Europeo de Desarrollo Regional) [AGL2006-14228-C03-02/ALI, AGL2009-13906-C02-01, AGL2010-10084-E, AGL2010-22319-C03-03]
- CONSOLIDER INGENIO Programme
- FUN-C-FOOD [CSD2007-063]
- CIberOBN an initiative of SCIII
- ISCII-Subdireccion General de Evaluacion y Fomento de la Investigacion [CNIC-06, PI11/02505, PI13/01172]
- Generalitat de Catalunya's Agency AGAUR [2014SGR1566]
- FPI fellowship
- Ramon y Cajal programmes of the Spanish Government
- Fondo Social Europeo
The Mediterranean diet (MD) is considered a dietary pattern with beneficial effects on human health. The aim of this study was to assess the effect of an MD on urinary metabolome by comparing subjects at 1 and 3 years of follow-up, after an MD supplemented with either extra-virgin olive oil (MD + EVOO) or nuts (MD + Nuts), to those on advice to follow a control low-fat diet (LFD). Ninety-eight nondiabetic volunteers were evaluated, using metabolomic approaches, corresponding to MD + EVOO (n = 41), MD + Nuts (n = 27), or LFD (n = 30) groups. The H-1 NMR urinary profiles were examined at baseline and after 1 and 3 years of follow-up. Multivariate data analysis (OSC-PLS-DA and HCA) methods were used to identify the potential biomarker discriminating groups, exhibiting a urinary metabolome separation between MD groups against baseline and LFD. Results revealed that the most prominent hallmarks concerning MD groups were related to the metabolism of carbohydrates (3-hydroxybutyrate, citrate, and cis-aconitate), creatine, creatinine, amino acids (proline, N-acetylglutamine, glycine, branched-chain amino acids, and derived metabolites), lipids (oleic and suberic acids), and microbial cometabolites (phenylacetylglutamine and p-cresol). Otherwise, hippurate, trimethylamine-N-oxide, histidine and derivates (methylhistidines, carnosine, and anserine), and xanthosine were predominant after LFD. The application of NMR-based metabolomics enabled the classification of individuals regarding their dietary pattern and highlights the potential of this approach for evaluating changes in the urinary metabolome at different time points of follow-up in response to specific dietary interventions.
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