期刊
JOURNAL OF PROTEOME RESEARCH
卷 13, 期 11, 页码 4497-4504出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr5005746
关键词
Carboxypeptidase; degradomics; proteolysis; biomarkers; protease; peptidase
资金
- Deutsche Forschungsgemeinschaft (DFG) [SCHI 871/2, SCHI 871/5, SFB850]
- European Research Council [ERC-2011-StG 282111-ProteaSys]
- Excellence Initiative of the German Federal and State Governments (BIOSS) [EXC 294]
- Marie Curie TIP fellowship (FP7-PEOPLE-IIF)
Carboxypeptidases are important mediators of cellular behavior. Through C-terminal truncations, they alter protein functionality and participate in proteome turnover. Similarly, carboxypeptidases shape the human peptidome by targeting neuroendocrine and vasoactive peptides, thereby regulating signaling pathways in the nervous and cardiovascular systems as well as in embryonic development. Carboxypeptidases are widely connected to various pathological processes such as carcinogenesis and neurodegenerative and cardiovascular diseases. The repertoire of carboxypeptidase in vivo substrates still remains poorly defined, largely due to the lack of suitable experimental approaches. Understanding the precise role of carboxypeptidases is pivotal in the future development of diagnostic/prognostic markers in such diseases. To date, very little attention has been paid to the implication of carboxypeptidases in shaping the proteome as well as the peptidome. This review focuses on the patho-physiological function of carboxypeptidases and highlights the approaches by which proteomics-based technologies can be applied to characterize carboxypeptidases and to quantify the differential regulation of proteins by carboxypeptidases in a proteome-wide manner.
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