期刊
JOURNAL OF PROTEOME RESEARCH
卷 11, 期 5, 页码 2937-2946出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr3000317
关键词
polycystic ovary syndrome; metabonomics; nuclear magnetic resonance; gut microflora; glycoprotein
资金
- Chinese Key Project for the Infectious Diseases [2008ZX10002-016]
- National Key Technologies R & D Program for New Drugs [2009XZ09301-002]
- National Natural Science Foundation of China [30973676, 81001419]
- National Natural Science Funds for Distinguished Young Scholar [30825038]
Polycystic ovary syndrome (PCOS) is a common, clinically heterogeneous endocrine disorder affecting women of reproductive age, associated with endocrinopathy and metabolic abnormalities. Although some metabolic parameters have been investigated, very little information has been reported on the changes of small metabolites in biofluids. The aim of this study was to establish the metabolic profile of PCOS and compare it with that of controls. In this cross-sectional study of 34 women with PCOS and 36 controls, contents of small metabolites and lipids in plasma samples were measured using nuclear magnetic resonance (NMR)-based techniques and analyzed using multivariate statistical methods. Significant decrease (P < 0.05) in the levels of amino acids (leucine, isoleucine, methionine, glutamine, and arginine), citrate, choline, and glycerophosphocholine/phosphocholine (GPC/PC), and increase (P < 0.05) in the levels of lactate, dimethylarnine (DMA), creatine, and N-acetyl glycoproteins were observed in PCOS patients compared with the controls. Subgroups of patients with obesity, metabolic syndrome, or hyperandrogenism exhibited greater metabolic deviations than their corresponding subgroups without these factors. PCOS patients have perturbations in amino acid metabolism, the tricarboxylic acid (TCA) cycle, and gut microflora, as well as mild disturbances in glucose and lipid metabolism. The elevated level of N-acetyl glycoproteins demonstrates the existence of low-grade chronic inflammation in PCOS
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