期刊
JOURNAL OF PROTEOME RESEARCH
卷 10, 期 1, 页码 66-84出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr100532g
关键词
biomarker; clinical proteomics; protein quantitation; post-translational modifications; multiple reaction monitoring mass spectrometry; enzyme-linked immunosorbent assay; immunohistochemistry; flow cytometry; nanotechnology; verification; qualification; genomics; The Cancer Genome Atlas
Significant progress has been made in characterizing and sequencing genomic alterations of biospecimens from several types of cancer. Understanding the functional changes in the human proteome that arise from the genomic alterations or other factors is the next logical step in the development of high-value protein biomarkers that can be transitioned to clinical studies for biomarker qualification. Linking advances in genomic analysis to proteomic analysis will provide a pathway for qualified biomarkers which can drive the rational development of new diagnostics and therapies. The availability of these multidimensional data to the scientific community sets the stage for the development of new molecularly targeted cancer interventions.
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