期刊
JOURNAL OF PROTEOME RESEARCH
卷 9, 期 8, 页码 3766-3780出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr1002609
关键词
carbonylation; oxidative stress; redox proteomics; reactive oxygen species; advanced glycation end products; lipid peroxidation adducts
资金
- national institute of aging [5R01AG025362-02]
- National Cancer Institute [1U24CA126480-01]
Excessive oxidative stress leaves a protein carbonylation fingerprint in biological systems. Carbonylation is an irreversible post-translational modification (PTM) that often leads to the loss of protein function and can be a component of multiple diseases. Protein carbonyl groups can be generated directly (by amino acids oxidation and the alpha-amidation pathway) or indirectly by forming adducts with lipid peroxidation products or glycation and advanced glycation end-products. Studies of oxidative stress are complicated by the low concentration of oxidation products and a wide array of routes by which proteins are carbonylated. The development of new selection and enrichment techniques coupled with advances in mass spectrometry are allowing the identification of hundreds of new carbonylated protein products from a broad range of proteins located at many sites in biological systems. The focus of this review is on the use of proteomics tools and methods to identify oxidized proteins along with specific sites of oxidative damage and the consequences of protein oxidation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据