期刊
JOURNAL OF PROTEOME RESEARCH
卷 9, 期 2, 页码 924-935出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr900747d
关键词
Intrauterine growth restriction; Piglets; Intestine; Development; Temporal proteomic analysis; Histological analysis
资金
- Natural Science Foundation of China [u0731001, 30810103902]
- Beijing Natural Science Foundation [6082017]
- Program for New Century Excellent Talents in University [NCET-08-0530]
- USDA National Institute of Food and Agriculture [2008-35203-19120, 2008-35206-18764]
- Texas AgriLife Research [H-82000]
Efficiency of nutrient utilization is reduced in neonates with intrauterine growth restriction (IUGR) compared with those with a normal birth weight (NBW). However, the underlying mechanisms are largely unknown. In this study, we applied temporal proteomic approach, coupled with histological and biochemical analyses, to study dynamic changes of the proteome in the small intestinal mucosa of IUGR piglets during the nursing period (Days 1, 7 and 21). We identified 56 differentially expressed protein spots between IUGR and NBW piglets. These proteins participate in key biological processes, including (1) absorption, digestion and transport of nutrients; (2) cell structure and motility; (3) glucose and energy metabolism; (4) lipid metabolism; (5) amino acid metabolism; (6) mineral and vitamin metabolism; (7) cellular redox homeostasis; (8) stress response; and (9) apoptosis. The results of our temporal proteomics analysis reveal continuous impairment of intestinal development in neonatal piglets with IUGR. The findings have important implications for understanding metabolic defects in the small intestine of IUGR neonates and are expected to provide new strategies to improve their survival and growth.
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