Metabonomics in Ulcerative Colitis

A recent publication in the Journal of Proteome Research applied metabolic profiling (metabonomics) to ulcerative colitis; several different biosamples were investigated (J. Proteome Res. 2010, 9, 954-962). Comparing urinary profiles, no differences were found between cases and controls; in a previously published study (Am. J. Gastroenterol. 2009, 104, 1435-1444), we had found significant differences. In this correspondence, the reasons for our experimental and analytical approach are explained, and the negative results of the Journal of Proteome Research study are discussed.