期刊
JOURNAL OF PROTEOME RESEARCH
卷 9, 期 2, 页码 689-699出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr901013d
关键词
diabetic retinopathy; vitreous; quantitative proteomics; biomarker; multiple reaction monitoring
资金
- Korean Ministry of Science and Technology [FPR 08-A2-110]
- Ministry of Health, Welfare and Family Affairs, Republic of Korea [00-PJ3-PG6-GN07-001, A030003]
Multiple reaction monitoring was used to verify target proteins in 3 groups of vitreous and plasma samples from 3 stages of diabetic retinopathy: macular hole (nondiabetic control), nonproliferative diabetic retinopathy, and proliferative diabetic retinopathy. Twelve target proteins were quantified using triple quadrupole LC-MS/MS and 3 methods to determine the transitions (information-dependent analysis, the MIDAS workflow, and the PepticleAtlas database). This study might be the first MRM experiment to analyze large numbers of clinical vitreous and plasma samples for biomarker verification. Consequently, several biomarker candidates were identified for use in further applications.
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