期刊
JOURNAL OF PROTEOME RESEARCH
卷 8, 期 1, 页码 113-117出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr800545q
关键词
Consensus; Serum collection; Plasma collection; Standard Operating Procedures; Biomarkers; Sample handling
资金
- NATIONAL CANCER INSTITUTE [U01CA086400] Funding Source: NIH RePORTER
- NCI NIH HHS [U01 CA086400, U01 CA086400-05] Funding Source: Medline
Specimen collection is an integral component of clinical research. Specimens from subjects with various stages of cancers or other conditions, as well as those without disease, are critical tools in the hunt for biomarkers, predictors, or tests that will detect serious diseases earlier or more readily than currently possible. Analytic methodologies evolve quickly. Access to high-quality specimens, collected and handled in standardized ways that minimize potential bias or confounding factors, is key to the bench to bedside aim of translational research. It is essential that standard operating procedures, the how of creating the repositories, be defined prospectively when designing clinical trials. Small differences in the processing or handling of a specimen can have dramatic effects in analytical reliability and reproducibility, especially when multiplex methods are used. A representative working group, Standard Operating Procedures Internal Working Group (SOPIWG), comprised of members from across Early Detection Research Network (EDRN) was formed to develop standard operating procedures (SOPs) for various types of specimens collected and managed for our biomarker discovery and validation work. This report presents our consensus on SOPs for the collection, processing, handling, and storage of serum and plasma for biomarker discovery and validation.
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