期刊
JOURNAL OF PROTEOME RESEARCH
卷 8, 期 7, 页码 3666-3674出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr800937k
关键词
MHC class I; MHC class II; phosphopeptide; renal cell carcinoma; titanium dioxide; phosphosite; Brf1; Frizzled 6; CXCR4; CD20
资金
- Deutsche Forschungsgemeinschaft [SFB 685]
- Bundesministerium fur Bildung und Forschung (BMBF, QuantPro)
- Stiftung der deutschen Wirtschaft - Studienstiftung Klaus Murmann
MHC molecules present protein-derived peptides to T lymphocytes. By developing TiO2-based microcentrifugation columns, we identified the first phosphorylated MHC class I ligands from tumor tissue (renal cell carcinoma) and, by comparison to healthy renal tissue, found one Brf1-derived ligand as potentially tumor-associated. We further discovered the first natural phosphorylated MHC class 11 ligands. They revealed several novel phosphorylation sites of significant transmembrane receptors, such as Frizzled 6, CXCR4 and CD20.
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