期刊
PHYSIOLOGY & BEHAVIOR
卷 151, 期 -, 页码 360-368出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2015.08.008
关键词
Antidepressant; Catalpol; Brain-derived neurotrophic factor; Cyclooxygenase-2; Chronic unpredictable mild stress
资金
- National Science & Technology Pillar Program of China [2011BAI06B02]
- Funding Scheme for Young Key Teachers of Colleges and Universities in Henan Province [2014GGJS-072]
- Provincial Fundamental Research Fund in Henan University of Chinese Medicine [2014KYYWF-QN01]
- National Science Foundation for Post-doctoral Scientists of China [2012M521412]
- National Natural Science Foundation of China [81473368]
- Innovation Program for Science & Technology Leading Talents of Zhengzhou City in China's Henan Province [121PLJRC534]
Catalpol, a major compound in Rehmannia glutinosa with both medicinal and nutritional values, has been previously confirmed to shorten the duration of immobility in mice exposed to tail suspension and forced swimming tests. This study attempted to examine the anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress (CUMS) by involving brain-derived neurotrophic factor (BDNF) and cyclooxygenase-2 (COX-2). CUMS-exposed rats were given catalpol daily (5, 10, and 20 mg/kg, ig) or a reference drug, fluoxetine hydrochloride (FH, 10 mg/kg, ig), at 5 weeks after starting the CUMS procedure. Sucrose preference test was performed to observe depression-like behavior, and serum and brain tissues were used for neurochemical and fluorescent quantitative reverse transcription PCR analysis. CUMS induced depression-like behavior, whereas catalpol and FH administration attenuated this symptom. Moreover, CUMS caused excessively elevated levels of serum corticosterone, an index of hypothalamic-pituitary-adrenal (HPA) axis hyperactivation, in a manner attenuated by catalpol and FH administration. Catalpol administration also further decreased BDNF activities, downregulated the mRNA expression of BDNF and tropomyosin-related kinase B (TrkB), and reversed the excessive elevation in the activities and mRNA expression levels of COX-2 and prostaglandin E-2 (PGE(2)) in the hippocampus and frontal cortex of rats undergoing CUMS. Results indicate that catalpol can ameliorate CUMS-induced depression-like behavior, and suggest its mechanisms may partially be ascribed to restoring HPA axis dysfunctions, upregulating BDNF expression and its cognate receptor TrkB, and downregulating COX-2 expression, thereby reducing PGE(2) levels in the brain. (C) 2015 Elsevier Inc. All rights reserved.
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