期刊
JOURNAL OF PROTEOME RESEARCH
卷 7, 期 8, 页码 3254-3266出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr700751y
关键词
folic acid deficiency; human colonocytes; NCM460; genomic stability; DNA repair; apoptosis; proteomics
Low folate intake is associated with colon cancer. We combined a proteomics and biochemical approach to identify proteins and pathways affected by folate deficiency in human colonocytes. Folate differentially altered activity and expression of proteins involved in proliferation [e.g., PCNA], DNA repair [e.g., XRCC5, MSH2], apoptosis [e.g., BAG family chaperone protein, DIABLO and porin], cytoskeletal organization [e.g., actin, ezrin, elfin], and expression of proteins implicated in malignant transformation [COMT, Nit2].
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